HEMATOCRIT increased White blood cells or platelets increased White blood cells or platelets normal JAK2 V617F mutation Serum erythropoietin Either one abnormal Both normal JAK 2 exon 12 mutation Abnormal Normal Evaluate for causes of relative polycythemia, or secondary polycythemia 1. Decreased fluid intake 2. Smoking - cigarette or nargila 3. Chronic lung disease 4. Sleep apnea 5. Testosterone use (men) 6. Kidney, liver, uterine, brain tumor Yes No Refer to hematologist for evaluation for Polycythemia Vera Investigate & treat appropriately Refer to hematologist for evaluation for Polycythemia Vera Refer to hematologist for evaluation Evaluate for causes of relative polycythemia, or secondary polycythemia 1. Decreased fluid intake 2. Smoking - cigarette or nargila 3. Chronic lung disease 4. Sleep apnea 5. Testosterone use (men) 6. Kidney, liver, uterine, brain tumor Yes No Back