Absolute neutrophil count < 1500/µl Chronic Acute Chronic Isolated Associated with other cytopenia Isolated Known autoimmune disorder Consider familial, congenital, ethnic causes Known autoimmune disorder Yes No Consider possible relationship to the underlying disorder. Consider familial, congenital, ethnic causes Yes No Refer to hematologist Counsel appropriately Splenomegaly Yes No Evaluate for systemic diseases causing splenomegaly eg liver disease, infection, storage disease Yes No Manage appropriately Refer to hematologist Acute No evidence of acute infection Evidence of acute infection Other cytopenia or splenomegaly Yes No Refer to hematologist Recent new drug administration Yes No Stop drug Not resolved Resolved Refer to hematologist Evaluate for infection Consider relationship to drug Back