HEMOGLOBIN decreased MCV or MCH decreased MCV and MCH normal MCV increased MCV or MCH decreased Red blood cell count normal / decreased Red blood cell count increased Red blood cell count normal / decreased Iron decreased Transferrin increased Transferrin saturation < 20% Ferritin decreased Iron decreased Transferrin normal / decreased Transferrin saturation normal / increased Ferritin normal / increased Iron normal Transferrin normal Transferrin saturation normal Ferritin normal Iron decreased Transferrin increased Transferrin saturation < 20% Ferritin decreased Iron deficiency Investigate cause and provide treatment Iron decreased Transferrin normal / decreased Transferrin saturation normal / increased Ferritin normal / increased Serum chemistry normal Serum chemistry abnormal Urea, Creatinine increased -> Renal investigation Globulins increased -> Myeloma investigation LDH increased -> Hemolysis investigation Serum Protein electrophoresis Immunofixation Immunoglobulin quantification Serum free light chains Abnormal Normal Refer to hematologist for investigation of myeloma CRP ESR Ferritin Increased Normal Investigate for systemic inflammatory disease or malignancy Testosterone levels Decreased Normal Refer to hematologist MCV increased Reticulocytes decreased or normal Reticulocytes increased Reticulocytes decreased or normal Vitamin B12 abnormal Folic acid abnormal Liver functions abnormal TSH abnormal Vitamin B12 normal Folic acid normal Liver functions normal TSH normal Investigate and treat appropriately Refer to hematologist for further assessment Reticulocytes increased LDH increased Bilirubin-indirect increased Haptoglobin decreased Direct Coombs Test normal Blood smear abnormal LDH normal Bilirubin-indirect normal Haptoglobin normal Direct coombs Test normal Blood smear normal LDH Bilirubin-indirect Haptoglobin Direct Coombs Test normal Blood smear abnormal Hemolytic Anemia Refer to hematologist for further assessment Evaluate for bleeding Hemoglobin electrophoresis HbA2 increased HbA2 normal Beta thalassemia Refer to hematologist for further testing for thalassemia Refer to endocrinologist Back